Nucleolar and Ribosomal DNA Structure under Stress: Yeast Lessons for Aging and Cancer.
Identifieur interne : 000268 ( Main/Exploration ); précédent : 000267; suivant : 000269Nucleolar and Ribosomal DNA Structure under Stress: Yeast Lessons for Aging and Cancer.
Auteurs : Emiliano Matos-Perdomo [Espagne] ; Félix Machín [Espagne]Source :
- Cells [ 2073-4409 ] ; 2019.
Descripteurs français
- KwdFr :
- ADN ribosomique (composition chimique), ADN ribosomique (génétique), Animaux (MeSH), Chromatine (génétique), Chromatine (métabolisme), Conformation d'acide nucléique (MeSH), Facteurs de transcription (génétique), Facteurs de transcription (métabolisme), Humains (MeSH), Levures (génétique), Levures (métabolisme), Points de contrôle du cycle cellulaire (génétique), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), Saccharomyces cerevisiae (génétique), Saccharomyces cerevisiae (métabolisme), Stress physiologique (génétique), Tumeurs (génétique), Tumeurs (métabolisme), Vieillissement (génétique), Épigénomique (MeSH).
- MESH :
- composition chimique : ADN ribosomique.
- génétique : ADN ribosomique, Chromatine, Facteurs de transcription, Levures, Points de contrôle du cycle cellulaire, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae, Stress physiologique, Tumeurs, Vieillissement.
- métabolisme : Chromatine, Facteurs de transcription, Levures, Protéines de Saccharomyces cerevisiae, Saccharomyces cerevisiae, Tumeurs.
- Animaux, Conformation d'acide nucléique, Humains, Épigénomique.
English descriptors
- KwdEn :
- Aging (genetics), Animals (MeSH), Cell Cycle Checkpoints (genetics), Chromatin (genetics), Chromatin (metabolism), DNA, Ribosomal (chemistry), DNA, Ribosomal (genetics), Epigenomics (MeSH), Humans (MeSH), Neoplasms (genetics), Neoplasms (metabolism), Nucleic Acid Conformation (MeSH), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Stress, Physiological (genetics), Transcription Factors (genetics), Transcription Factors (metabolism), Yeasts (genetics), Yeasts (metabolism).
- MESH :
- chemical , chemistry : DNA, Ribosomal.
- chemical , genetics : Chromatin, DNA, Ribosomal, Saccharomyces cerevisiae Proteins, Transcription Factors.
- genetics : Aging, Cell Cycle Checkpoints, Neoplasms, Saccharomyces cerevisiae, Stress, Physiological, Yeasts.
- chemical , metabolism : Chromatin, Neoplasms, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription Factors, Yeasts.
- Animals, Epigenomics, Humans, Nucleic Acid Conformation.
Abstract
Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar biology include the nucleolar stress response (NSR), whereby a series of cell insults have a special impact on the nucleolus. These insults include, among others, ultra-violet radiation (UV), nutrient deprivation, hypoxia and thermal stress. While these stresses might influence nucleolar biology directly or indirectly, other perturbances whose origin resides in the nucleolar biology also trigger nucleolar and systemic stress responses. Among the latter, we find mutations in nucleolar and ribosomal proteins, ribosomal RNA (rRNA) processing inhibitors and ribosomal DNA (rDNA) transcription inhibition. The p53 protein also mediates NSR, leading ultimately to cell cycle arrest, apoptosis, senescence or differentiation. Hence, NSR is gaining importance in cancer biology. The nucleolar size and ribosome biogenesis, and how they connect with the Target of Rapamycin (TOR) signalling pathway, are also becoming important in the biology of aging and cancer. Simple model organisms like the budding yeast Saccharomyces cerevisiae, easy to manipulate genetically, are useful in order to study nucleolar and rDNA structure and their relationship with stress. In this review, we summarize the most important findings related to this topic.
DOI: 10.3390/cells8080779
PubMed: 31357498
PubMed Central: PMC6721496
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Factors (genetics)</term><term>Transcription Factors (metabolism)</term><term>Yeasts (genetics)</term><term>Yeasts (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN ribosomique (composition chimique)</term><term>ADN ribosomique (génétique)</term><term>Animaux (MeSH)</term><term>Chromatine (génétique)</term><term>Chromatine (métabolisme)</term><term>Conformation d'acide nucléique (MeSH)</term><term>Facteurs de transcription (génétique)</term><term>Facteurs de transcription (métabolisme)</term><term>Humains (MeSH)</term><term>Levures (génétique)</term><term>Levures (métabolisme)</term><term>Points de contrôle du cycle cellulaire (génétique)</term><term>Protéines de Saccharomyces cerevisiae (génétique)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>Saccharomyces cerevisiae (génétique)</term><term>Saccharomyces cerevisiae (métabolisme)</term><term>Stress physiologique (génétique)</term><term>Tumeurs (génétique)</term><term>Tumeurs 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cellulaire</term><term>Protéines de Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae</term><term>Stress physiologique</term><term>Tumeurs</term><term>Vieillissement</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Chromatin</term><term>Neoplasms</term><term>Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae Proteins</term><term>Transcription Factors</term><term>Yeasts</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Chromatine</term><term>Facteurs de transcription</term><term>Levures</term><term>Protéines de Saccharomyces cerevisiae</term><term>Saccharomyces cerevisiae</term><term>Tumeurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Epigenomics</term><term>Humans</term><term>Nucleic Acid Conformation</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Conformation d'acide nucléique</term><term>Humains</term><term>Épigénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar biology include the nucleolar stress response (NSR), whereby a series of cell insults have a special impact on the nucleolus. These insults include, among others, ultra-violet radiation (UV), nutrient deprivation, hypoxia and thermal stress. While these stresses might influence nucleolar biology directly or indirectly, other perturbances whose origin resides in the nucleolar biology also trigger nucleolar and systemic stress responses. Among the latter, we find mutations in nucleolar and ribosomal proteins, ribosomal RNA (rRNA) processing inhibitors and ribosomal DNA (rDNA) transcription inhibition. The p53 protein also mediates NSR, leading ultimately to cell cycle arrest, apoptosis, senescence or differentiation. Hence, NSR is gaining importance in cancer biology. The nucleolar size and ribosome biogenesis, and how they connect with the Target of Rapamycin (TOR) signalling pathway, are also becoming important in the biology of aging and cancer. Simple model organisms like the budding yeast <i>Saccharomyces cerevisiae</i>, easy to manipulate genetically, are useful in order to study nucleolar and rDNA structure and their relationship with stress. In this review, we summarize the most important findings related to this topic.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31357498</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>09</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2073-4409</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>8</Issue><PubDate><Year>2019</Year><Month>07</Month><Day>26</Day></PubDate></JournalIssue><Title>Cells</Title><ISOAbbreviation>Cells</ISOAbbreviation></Journal><ArticleTitle>Nucleolar and Ribosomal DNA Structure under Stress: Yeast Lessons for Aging and Cancer.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E779</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/cells8080779</ELocationID><Abstract><AbstractText>Once thought a mere ribosome factory, the nucleolus has been viewed in recent years as an extremely sensitive gauge of diverse cellular stresses. Emerging concepts in nucleolar biology include the nucleolar stress response (NSR), whereby a series of cell insults have a special impact on the nucleolus. These insults include, among others, ultra-violet radiation (UV), nutrient deprivation, hypoxia and thermal stress. While these stresses might influence nucleolar biology directly or indirectly, other perturbances whose origin resides in the nucleolar biology also trigger nucleolar and systemic stress responses. Among the latter, we find mutations in nucleolar and ribosomal proteins, ribosomal RNA (rRNA) processing inhibitors and ribosomal DNA (rDNA) transcription inhibition. The p53 protein also mediates NSR, leading ultimately to cell cycle arrest, apoptosis, senescence or differentiation. Hence, NSR is gaining importance in cancer biology. The nucleolar size and ribosome biogenesis, and how they connect with the Target of Rapamycin (TOR) signalling pathway, are also becoming important in the biology of aging and cancer. Simple model organisms like the budding yeast <i>Saccharomyces cerevisiae</i>, easy to manipulate genetically, are useful in order to study nucleolar and rDNA structure and their relationship with stress. In this review, we summarize the most important findings related to this topic.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Matos-Perdomo</LastName><ForeName>Emiliano</ForeName><Initials>E</Initials><Identifier Source="ORCID">0000-0001-9783-3591</Identifier><AffiliationInfo><Affiliation>Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Escuela de Doctorado y Estudios de Postgrado, Universidad de La Laguna, 38200 Tenerife, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Machín</LastName><ForeName>Félix</ForeName><Initials>F</Initials><Identifier Source="ORCID">0000-0003-4559-7798</Identifier><AffiliationInfo><Affiliation>Unidad de Investigación, Hospital Universitario Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain. fmachin@funcanis.es.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Instituto de Tecnologías Biomédicas, Universidad de La Laguna, 38200 Tenerife, Spain. fmachin@funcanis.es.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Facultad de Ciencias de la Salud, Universidad Fernando Pessoa Canarias, 35450 Santa María de Guía, Gran Canaria, Spain. fmachin@funcanis.es.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>07</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Cells</MedlineTA><NlmUniqueID>101600052</NlmUniqueID><ISSNLinking>2073-4409</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002843">Chromatin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004275">DNA, Ribosomal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029701">Saccharomyces cerevisiae Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C561842">TORC1 protein complex, S cerevisiae</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014157">Transcription Factors</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000375" MajorTopicYN="N">Aging</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059447" MajorTopicYN="N">Cell Cycle Checkpoints</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002843" MajorTopicYN="N">Chromatin</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004275" MajorTopicYN="N">DNA, Ribosomal</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057890" MajorTopicYN="N">Epigenomics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009690" MajorTopicYN="Y">Nucleic Acid Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029701" MajorTopicYN="N">Saccharomyces cerevisiae Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014157" MajorTopicYN="N">Transcription Factors</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015003" MajorTopicYN="N">Yeasts</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">TORC1</Keyword><Keyword MajorTopicYN="Y">aging</Keyword><Keyword MajorTopicYN="Y">cancer</Keyword><Keyword MajorTopicYN="Y">nucleolar condensation</Keyword><Keyword MajorTopicYN="Y">nucleolar stress</Keyword><Keyword MajorTopicYN="Y">ribosome biogenesis</Keyword><Keyword MajorTopicYN="Y">sirtuins</Keyword><Keyword MajorTopicYN="Y">yeast nucleolus</Keyword><Keyword MajorTopicYN="Y">yeast rDNA</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>06</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>07</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>07</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>7</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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